advances in tissue engineering of blood vessels and other tissues

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. 2020 Jul 27;11(8):727. doi: 10.3390/mi11080727. Get the latest public health information from CDC: They constructed a vessel by seeding cultured bovine aortic ECs, SMCs, and adventitial fibroblasts on a collagen-coated thin Dacron mesh scaffold (. Human bladder SMC suspension spun at 2500 rpm with porous PGA scaffolds reportedly has greater seeding efficiency than static or spinner flask techniques and has led to more homogeneous deposition (. Innovative scaffold fabrication, angiogenesis promotion, and dynamic tissue culture techniques have been utilized to improve delivery of media into the core of large tissue constructs in tissue engineering. Endothelial and vascular smooth muscle cell function on poly(lactic-co-glycolic acid) with nano-structured surface features. Regulation of cell adhesion and migration by cell-derived matrices. demonstrated delayed leukocyte involvement in decellularized tracheal allografts recellularized with autologous MSCs implanted in porcine models (. C.K.O. Synthetic polymer materials that are biocompatible, non-immunogenic, and degradable are also being explored for use as scaffolds, including polyglycolic acid (PGA), polycaprolactone (PCL), poly-L-lactide (PLLA), and mixtures thereof. Cdh5/VE-cadherin promotes endothelial cell interface elongation via cortical actin polymerization during angiogenic sprouting. Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Although vascular cells can contribute paracrine factors and have regenerative capacity, merely delivering a dispersed mixture of ECs to the host tissue has shown limited success at forming vasculature or integrating with the host vasculature (. Gene Ther 8(7):523–533, Lutolf MP, Hubbell JA (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Vascularization: T Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Preliminary studies have achieved good cell densities of both smooth muscle cells and endothelial cells on biodegradable polymer scaffolds. Endothelial cell-pericyte interactions stimulate basement membrane matrix assembly: influence on vascular tube remodeling, maturation, and stabilization. Nat Med 9(6):685–693, Maton A (1994) Human biology and health, 3rd edn. One of the main issues in this approach is the limited viability of transplanted cells because ... Collagen-fibronectin gels containing Bcl-2–transduced human umbilical vein endothelial cells (Bcl-2-HUVEC) implanted in the abdominal walls of immunodeficient mice form mature microvessels invested by host-derived smooth muscle cells (SMC) by 8 weeks. generated ECs from adipose-derived stromal cells, transfected them with adenoviral vector carrying the endothelial nitric oxide synthase (eNOS) gene, and seeded the ECs onto decellularized human saphenous vein scaffolds (. 2019 Aug;3(8):1900089. doi: 10.1002/adbi.201900089. Although the clinical demand for bioengineered blood vessels continues to rise, current options for vascular conduits remain limited. To minimize contamination during the weeks of tissue culture required to produce an arterial prosthesis, a sterile incubator system was developed. Vascul Pharmacol 56(5–6):288–296, Schoen FJ (2011) Heart valve tissue engineering: quo vadis? Scaffold-free vascular tissue engineering using bioprinting. Artificial small-diameter blood vessels: materials, fabrication, surface modification, mechanical properties, and bioactive functionalities. Collagen and elastin biomaterials for the fabrication of engineered living tissues. Vascular Microphysiological Systems to Model Diseases. We also highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology. Tissue Eng Part A 15(7):1751–1761, Tsigkou O, Pomerantseva I, Spencer JA et al (2010) Engineered vascularized bone grafts. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The ability to withstand physiologic pressures without employing a synthetic mesh within the scaffold, however, remained a mystery until L’Heureux et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. 2015 Aug;9(8):861-88. doi: 10.1002/term.1697. Most of these procedures are in small calibre (<6 mm) vessels, for which synthetic graft materials are not generally suitable. Biophys J 94(1):273–285. Part of Springer Nature. Circulation 119(2):290–297, Wang L, Wilshaw S-P, Korossis S et al (2009) Factors influencing the oxygen consumption rate of aortic valve interstitial cells: application to tissue engineering. Tubular scaffolds have been specially designed for culturing small calibre arteries in vitro. Here we explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. Harnessing the regenerative functions reported in ECs derived from adult stem cells and iPSCs offers the promise of improving TEBV patency. This service is more advanced with JavaScript available, Engineering in Translational Medicine Lab Invest 83(12):1811–1820, Kaufman DS (2001) Hematopoietic colony-forming cells derived from human embryonic stem cells. Three-dimensional bioprinting of thick vascularized tissues. Polymer scaffolds used in tissue engineering are generally biodegradable, often involving compounds which are already approved for human implantation. In vivo analysis reveals a highly stereotypic morphogenetic pathway of vascular anastomosis. Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Ischemic diseases, such as atherosclerotic cardiovascular disease (CVD), remain one of the leading causes of mortality and morbidity across the world (. employed alginate as a sacrificial mold that could be washed with a sodium citrate solution once embedded in collagen gel containing neonatal human dermal fibroblasts (.  |  Human skin constructs with spatially controlled vasculature using primary and iPSC-derived endothelial cells. Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Major advances have been made in the field of tissue engineering since the topic of lymphatic engineering was taken up by this journal 5 years ago. 2019 Sep 6;5(9):eaaw2459. The global diffusion of organ transplantation: trends, drivers and policy implications. Nat Methods 5(5):439–445, Sorrell JM, Baber MA, Caplan AI (2009) Influence of adult mesenchymal stem cells on in vitro vascular formation. Advances in tissue engineering of blood vessels and other tissues. Transplant Immunology 1997; 5: 303-306 Advances in tissue engineering of blood vessels and other tissues Laura E Niklasona?b and Robert S Langerb aDepartment of Anaesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, bDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts Received 21 May 1997 Abstract: Tissue … Amplified photodegradation of cell-laden hydrogels via an addition-fragmentation chain transfer reaction. J Biomater Sci Polym Ed 20(12):1763–1779, Saik JE, Gould DJ, Keswani AH et al (2011) Biomimetic hydrogels with immobilized Ephrin-A1 for therapeutic angiogenesis. Multilineage communication regulates human liver bud development from pluripotency. Tissue engineering combines the fields of medicine and engineering to build replacement tissue capable of restoring, maintaining, or improving damaged tissue. Cellular engineering of vascular bypass grafts: role of chemical coatings for enhancing endothelial cell attachment. J Cell Sci 112(19):3249–3258, Simionescu A, Schulte JB, Fercana G et al (2011) Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview. eCollection 2019 Sep. Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications. Copyright © 1997 Published by Elsevier B.V. Arterial-venous specification during development. Circ Res 102(6):637–652, Sainson RC, Aoto J, Nakatsu MN et al (2005) Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. Tissue Eng Part A 16(2):585–594, Cheng G, Liao S, Wong HK et al (2011) Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis. Studies have revealed the immunotolerant potential of stem cells. 1998 Nov;19(21):1945-55. doi: 10.1016/s0142-9612(98)00099-4. In vitro engineering of vascularized tissue surrogates. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Hydrogels to model 3D in vitro microenvironment of tumor vascularization. Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectin.

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